Paediatric and Teenage Nutrition

food, feeding and nutrition

Tag: delayed reactions

positive outcomes for cow’s milk allergy

Positive outcomes for cow’s milk allergy is the 4th in the 5-part blog series on Cow’s Milk Allergy in Infancy and is best read following treatment options for cow’s milk allergy.

Around 50% of infants with non-IgE Cow’s Milk Allergy tolerate milk by age 1. Positive outcomes for Cow’s Milk Allergy depend on a number of factors including the type and severity of symptoms; the length of time taken to confirm a diagnosis; and the infants ability to tolerate exposure to baked and fermented milk. Good ongoing dietary management and support, helps those positive outcomes for cow’s milk firstly by ensuring symptoms are settled and supported with a milk free diet whilst breastfeeding or with the most suitable formula. Mum and baby can then develop confidence with feeding; mum managing the learning curve of a cow’s milk free diet, and baby learning that feeding doesn’t hurt.

Active Allergy Management
Only once there are no residual symptoms for at least 3 months exposure maybe considered; firstly to small amounts of baked milk and then fermented milk or yoghurt.  Active Allergy Management involves the deliberate introduction of small amounts of milk proteins at the right time. This helps to educate the immune system and develop tolerance.  Acquiring tolerance in this way speeds up the return to a normal diet. Considerations then:

Type and severity of symptoms
Infants with severe or immediate reactions (IgE) take longer to out grow their allergy. Those infants should not consume cow’s milk products within the first year after diagnosis, although 75% can tolerate small amounts of yoghurt by age 2.   For delayed reactions (non-IgE) such as reflux – see identifying symptoms of cow’s milk allergy most infants (>50%) have outgrown their allergy by their first birthday.

Length of time taken to confirm a diagnosis
In a 2015 survey, the average length of time taken to confirm a diagnosis was 4-5 weeks and 10 GP visits.  I am now seeing infants at a much earlier stage, due mainly to increased awareness in GP’s and in families. Early intervention is the key to seeing those positive outcomes for cow’s milk allergy at an earlier stage. In general, the longer it takes to identify symptoms, and confirm a diagnosis the longer it will take to acquire tolerance.

Ability to tolerate exposure to baked and fermented cow’s milk
Exposure and tolerance to baked and fermented cow’s milk, with the use of the Milk Ladder has seen more positive outcomes for cow’s milk allergy at an earlier stage. The Milk Ladder provides evidence based stepwise reintroduction of milk products; which can usually begin around 9 months of age. The latest version is available to download from the Allergy UK website.

Next Innovative Treatments in Cow’s Milk Allergy

identifying the symptoms of cow’s milk allergy

Identifying the symptoms of Cow’s Milk Allergy is the 1st part in this 5-part blog series about Cow’s Milk Allergy in Infancy.

Cow’s Milk Allergy (CMA) is an immune reaction to the proteins found in cow’s milk affecting 1 in 20 infants in the UK.  There are two distinct types of cow’s milk allergy: IgE reactions with immediate onset of symptoms and non IgE reactions with delayed onset.  In both types, symptoms range from mild-moderate to severe and persisting with potentially life-threatening reactions such as anaphylaxis. The following table will help you in identifying the symptoms of Cow’s Milk Allergy.

Delayed Onset Symptoms

Non-IgE Cow’s Milk Allergy

2 – 72 hours after milk intake

Immediate Onset Reactions

IgE Cow’s Milk Allergy

Minutes after milk intake

Affecting formula-fed, exclusively breast fed infants or at the onset of mixed feeding/solids Affecting formula-fed infants or at the onset of mixed feeding
Gastrointestinal symptoms may be mild-moderate or severe and persisting
colic, reflux, loose, frequent stools, soft stool constipation, painful wind,  blood or mucous in nappy, food refusal, feeding aversion, poor growth vomiting, diarrhoea, colic
Skin symptoms can be mild-moderate or severe and persisting
itchy, raised red rash, atopic eczema intense itching, erythema (raised red rash), urticaria (flushing, spreading rash), flare up of atopic eczema, angioedema (facial swelling)
Respiratory symptoms are confined to IgE reactions
acute rhinitis (hayfever), conjunctivitis (swelling in and around the eyes) ANAPHYLAXIS

This blog series will focus on non-IgE CMA with delayed onset, which although less severe can be more complex and difficult to diagnose.  This is due to a number of issues: the similarity to other common conditions during infancy such as colic, reflux or loose stools and also the symptoms being mistakenly treated as lactose intolerance. Again this is due to the similarity in gut symptoms such as colic, bloating, discomfort and diarrhoea.  Unlike IgE CMA, there is no diagnostic allergy test for non IgE CMA and because reactions are delayed up to 72 hours after intake, cause and effect is not quite so clear. Lactose intolerance does not involve immune reactions, but results from lack of the digestive enzyme lactase, with malabsorption of the “milk sugar” lactose  causing discomfort and diarrhoea. A lactose free formula (which normally contains cow’ s milk protein) will resolve lactose intolerance but not Cow’s Milk Allergy,

Non IgE Cow’s Milk Allergy in infancy responds extremely well to prompt dietary treatment, with the majority of infants outgrowing their allergy within 6-12 months.  Delays in diagnosis and treatment lead to symptoms becoming severe and persistent, with feeding difficulties and growth faltering more evident.  Identifying the symptoms of Cow’s Milk Allergy early and discussing an allergy focused history with a trained GP or Paediatric Dietitian will assist making a diagnosis and accessing prompt appropriate treatment.

Next Confirming a diagnosis of Cow’s Milk Allergy.